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Porphyrins Profile

Porphyrins Profile

Regular price $299.00 USD
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Specimen Requirement

10 mL urine minimum.

Please see collection instructions for detailed instructions.

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Genetic Deficiencies in Heme Production

The Porphyrins Profile measures the level of porphyrins in urine. High levels of porphyrins may indicate porphyria.  Porphyria refers to a group of inherited or acquired diseases that prevent your body from correctly making heme, the precursor to hemoglobin. Elevated urine levels of porphyrins result from inhibition of key enzymatic steps, this can be from genetic deficiencies in heme production enzymes, hepatitis, renal disease, erythroid disease, as well as by heavy metal inhibition of heme enzyme synthesis. Elevated levels of urinary porphyrins have been found in both experimental animals and humans exposed to heavy metals.

  • What Patients Might Benefit

    • Alcoholism
    • Certain Skin Cancers
    • Chronic Kidney Disease
    • Heavy Metal Poisoning
    • Hepatocellular Carcinoma
    • Liver Disease
    • Muscle Weakness
    • Nausea, Vomiting, Diarrhea, & Constipation
    • Neurological Symptoms
    • Seizures
  • Details

    The profile includes markers that are intermediates in the heme synthesis pathway. Abnormal levels of these porphyrins can indicate a number of different disorders, including porphyrias, lead poisoning, liver diseases, and certain types of cancers.


    • Coproporphyrin I and III (CP)
    • Heptacarboxy (7-CP)
    • Hexacarboxy (6-CP)
    • Pentacarboxy (5-CP)
    • Precoproporphyrin (PreCP)
    • Uroporphyrins (UP)